Maro Publications

Cyclodextrin

Notes

Patent Abstracts

Patent Titles

From 06/26/2014 through 7/9/2013

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Polysaccharides

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Patent Titles

11/12/2013

8. 8,580,244 
Cyclodextrin-based polymers for therapeutics delivery 

7. 8,580,243 
Cyclodextrin-based polymers for therapeutics delivery 

6. 8,580,242 
Cyclodextrin-based polymers for therapeutics delivery 

10/1/2013

5. 8,546,355 
Compositions comprising cyclodextrin 

8/27/2013

4. 8,518,388 
Cyclodextrin-based polymers for therapeutics delivery 

8/6/2013

3. 8,501,308 
Grafted cyclodextrin 

7/30/2013 

2. 8,497,365 
Cyclodextrin-based polymers for therapeutics delivery

7/9/2013

1. 8,481,127 
Cyclodextrin compositions, articles, and methods 

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Notes

“Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclic oligosaccharides).

Cyclodextrins are produced from starch by means of enzymatic conversion. They are used in food, pharmaceutical,[1] drug delivery,[2] and chemical industries, as well as agriculture and environmental engineering. Hydroxypropyl Beta Cyclodextrin (HPβCD) is the chief active compound found in Procter and Gamble's deodorizing product "Febreze" under the brand name "Clenzaire".

Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). The 5-membered macrocycle is not natural. Recently, the largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape:”

(Cyclodextrin, Wikipedia, 7/29/2013)

“Cyclodextrins are known to be useful for their ability to reversibly form inclusion complexes, sometimes referred to as clathrates, with many types of compounds. This ability results from the molecular shape, which has been likened to a doughnut or a truncated cone with a cylindrically-shaped cavity formed in the center of the doughnut or truncated cone. The outer surface of cyclodextrin is generally hydrophilic, while the interior cavity is generally hydrophobic. The hydrophilic outer portion allows free cyclodextrins to be water soluble. The hydrophobic interior cavity allows the cyclodextrins to absorb or form inclusion complexes with, e.g., organic compounds of appropriate size. In .alpha.-CD, the interior cavity has a diameter of about 5 angstroms; the interior cavity of .beta.-CD has a diameter of about 7 angstroms, and the interior cavity of .gamma.-CD has a diameter of about 9 angstroms. The interior cavities of all three cyclodextrins have a depth of about 7 angstroms.”  (Wilcox and Paesen, US Patent 8,741,977, 6/3/2014)

 

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Patent Abstracts

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Interested!!
Bookmark this page to follow future developments!.
(RDC 7/16/2012)

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Roger D. Corneliussen
Editor
www.maropolymeronline.com

Maro Polymer Links
Tel: 610 363 9920
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E-Mail: cornelrd@bee.net  

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Copyright 2013 by Roger D. Corneliussen.
No part of this transmission is to be duplicated in any manner or forwarded by electronic mail without the express written permission of Roger D. Corneliussen
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* Date of latest addition; date of first entry is 7/29/2013.